abstract：BACKGROUND AND AIM:Monotherapy has been proven insufficient in achieving sustained control of chronic hepatitis B. We aimed to assess the efficacy of combined sequential administration of lamivudine and pegylated interferon alfa-2b in patients with hepatitis Be antigen (HBeAg)-negative chronic hepatitis B. METHODS:Eig...

journal_title：Journal of gastroenterology and hepatology

authors： Vassiliadis T,Tziomalos K,Patsiaoura K,Zagris T,Giouleme O,Soufleris K,Grammatikos N,Theodoropoulos K,Mpoumponaris A,Dona K,Zezos P,Nikolaidis N,Orfanou-Koumerkeridou E,Balaska A,Eugenidis N

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND AND AIM:Although gastric hypermotility is one of the mechanisms proposed to explain the ulcerogenic action of indomethacin, the drug has shown relaxatory effects on isolated longitudinal and transverse rat gastric fundus. To explain the above discrepancy, the aim of this study was to investigate the effects ...

journal_title：Journal of gastroenterology and hepatology

authors： Keshavarz M,Afshin S,Djahanguiri B

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND AND AIM:There are few studies investigating the treatment of hepatitis C virus (HCV) infection in current and former drug users. With this in mind, we sought to evaluate the antiviral efficacy of interferon alpha-2b (IFN alpha-2b) or pegylated-interferon alpha-2b (PEG-IFN alpha-2b) and ribavirin (RBV) in inj...

journal_title：Journal of gastroenterology and hepatology

authors： Grebely J,Raffa JD,Meagher C,Duncan F,Genoway KA,Khara M,McLean M,Mead A,Viljoen M,DeVlaming S,Fraser C,Conway B

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND AND AIM:To evaluate the optimal dosage of rabeprazole for proton-pump inhibitor (PPI) testing of gastroesophageal reflux disease (GERD) and to test the influence of cytochrome P450 (CYP) 2C19 polymorphism in a population with a high prevalence of people who metabolize PPI poorly. METHODS:In this randomized,...

journal_title：Journal of gastroenterology and hepatology

authors： Lee YC,Lin JT,Wang HP,Chiu HM,Wu MS

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND AND AIM:Host genetic factors have been reported as influencing the progress to fulminant hepatitis (FH). Our previous data showed the serum level of tumor necrosis factor (TNF)-alpha influenced by gene polymorphisms to be markedly increased. It was investigated whether polymorphisms in the IL-10 gene, in add...

journal_title：Journal of gastroenterology and hepatology

authors： Takakura M,Tokushige K,Matsushita N,Hashimoto E,Shiratori K

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Clinical trials of probiotic treatment for Crohn's disease (CD) have yielded conflicting results. This study assessed the clinical usefulness of combined probiotic and prebiotic therapy in the treatment of active CD. METHOD:Ten active CD outpatients without history of operation for CD were enrolled. Their m...

journal_title：Journal of gastroenterology and hepatology

authors： Fujimori S,Tatsuguchi A,Gudis K,Kishida T,Mitsui K,Ehara A,Kobayashi T,Sekita Y,Seo T,Sakamoto C

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND AND AIM:The risk of hepatocellular carcinoma (HCC) is known to be age dependent; the influence of age on prognosis is, however, controversial. The aim of this study was to compare the tumor characteristics and survival rates of young and old HCC patients, with respect to tumor stage. METHODS:We reviewed the...

journal_title：Journal of gastroenterology and hepatology

authors： Cho SJ,Yoon JH,Hwang SS,Lee HS

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND AND AIM:The authors' previous report revealed that endothelin-1 might be released from B lymphocytes in cirrhotic patients with hypersplenism. Other investigators have shown that persistent exposure to environmental contaminants including arsenic might induce idiopathic portal hypertension. The aim of this s...

journal_title：Journal of gastroenterology and hepatology

authors： Yamaguchi E,Yamanoi A,Ono T,Nagasue N

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Slow waves play an important role in controlling the frequency and propagation of gastrointestinal contractions. However, mechanisms involved in the modulation of slow wave activity in vivo are still unclear. In this study, the roles of different neurotransmitters in the regulation of gastrointestin...

journal_title：Journal of gastroenterology and hepatology

authors： Liu S,Xu J,Chen JDz

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND AND AIM:It has recently been reported that Toll-like receptor 4 (TLR4) is involved in cellular responses to lipopolysaccharides (LPS) and early liver injury induced by LPS. The aim of the present study was to investigate the alterations of TLR4 gene expression in liver tissues and Kupffer cells during the co...

journal_title：Journal of gastroenterology and hepatology

authors： Hua J,Qiu DK,Li JQ,Li EL,Chen XY,Peng YS

更新日期：2007-06-01 00:00:00

abstract：:Brief periods of tissue ischemia produced tissue resistance to prolonged ischemia and reperfusion, a phenomenon called ischemic preconditioning. The mechanisms of ischemic preconditioning were examined in a rat warm ischemia-reperfusion model as well as the effect of ischemic preconditioning on liver regeneration. Isc...

journal_title：Journal of gastroenterology and hepatology

authors： Arai M,Tejima K,Ikeda H,Tomiya T,Yanase M,Inoue Y,Nagashima K,Nishikawa T,Watanabe N,Omata M,Fujiwara K

更新日期：2007-06-01 00:00:00

abstract：:The Swift Increase in Alcohol Metabolism occurs within 2.5 h after an acute gavage of ethanol causing an increase in hepatic respiration, an increase in alcohol metabolism, and pericentral hypoxia in the perfused liver. Alcohol treatment causes a release of endotoxin, activation of Kupffer cells to produce PGE(2), the...

journal_title：Journal of gastroenterology and hepatology

authors： Bradford BU

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND AND AIM:Ulcerative colitis (UC) is a multifactorial disease resulting from a complex interaction of genetic and environmental factors. Identifying genetic variants that alter the innate immune response is highly relevant to understanding the pathogenesis of UC. The aim of this study was to investigate the as...

journal_title：Journal of gastroenterology and hepatology

authors： Wang F,Tahara T,Arisawa T,Shibata T,Nakamura M,Fujita H,Iwata M,Kamiya Y,Nagasaka M,Takahama K,Watanabe M,Hirata I,Nakano H

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND AND AIM:Nonalcoholic steatohepatitis (NASH) is a metabolic disorder of the liver that may evolve into fibrosis or cirrhosis. Recent studies have shown reduction of experimental liver fibrosis with the use of angiotensin-converting-enzyme inhibitors or angiotensin-receptor antagonists. The aim of this study w...

journal_title：Journal of gastroenterology and hepatology

authors： Ibañez P,Solis N,Pizarro M,Aguayo G,Duarte I,Miquel JF,Accatino L,Arrese M

更新日期：2007-06-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in Western industrialized countries, affecting 20-40% of the general population. Large population-based surveys in China, Japan, and Korea indicate that the prevalence of NAFLD is now 12% to 24% in population subgroups, depending on age, gende...

journal_title：Journal of gastroenterology and hepatology

authors： Chitturi S,Farrell GC,Hashimoto E,Saibara T,Lau GK,Sollano JD,Asia-Pacific Working Party on NAFLD.

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to evaluate the influence of a younger age at the time of ileal pouch-anal anastomosis (IPAA) on functional outcome and quality of life in patients with familial adenomatous polyposis (FAP). METHOD:A total of 105 patients with FAP who had undergone IPAA were retrieved from a...

journal_title：Journal of gastroenterology and hepatology

authors： Erkek AB,Church JM,Remzi FH

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:The efficacy and safety of peginterferon alpha-2a (40 KD) (peg-IFNalpha-2a) plus ribavirin has not been reported for Japanese patients with chronic hepatitis C. The aim of this study was to evaluate this combination in treatment-naïve patients and in non-responders or relapsers to interferon monotherapy. ME...

journal_title：Journal of gastroenterology and hepatology

authors： Kuboki M,Iino S,Okuno T,Omata M,Kiyosawa K,Kumada H,Hayashi N,Sakai T

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND AND AIM:Cytokines play an important role in the pathogenesis of acute pancreatitis (AP). The aim of the present paper was to study the profile of anti- and proinflammatory cytokines in AP and to determine their predictive value for severity of AP, organ failure and mortality. METHODS:Consecutive patients wi...

journal_title：Journal of gastroenterology and hepatology

authors： Sathyanarayan G,Garg PK,Prasad H,Tandon RK

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:The pathogenesis of non-alcoholic steatohepatitis (NASH) is unclear. Recent studies suggested that oxidative stress plays an important role in the mechanism of NASH. Excessive accumulation of iron in the liver causes oxidative stress. The aim of the present study was to evaluate the grade of hepatic iron acc...

journal_title：Journal of gastroenterology and hepatology

authors： Yamamoto M,Iwasa M,Iwata K,Kaito M,Sugimoto R,Urawa N,Mifuji R,Konishi M,Kobayashi Y,Adachi Y

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND AND AIM:Abdominal wall hernia is a common feature of decompensated liver cirrhosis and frequently causes life-threatening complications or severe pain. However, there have been no data reported on postoperative mortality, hepatic functional deterioration and recurrence rate according to Child-Turcotte-Pugh (...

journal_title：Journal of gastroenterology and hepatology

authors： Park JK,Lee SH,Yoon WJ,Lee JK,Park SC,Park BJ,Jung YJ,Kim BG,Yoon JH,Kim CY,Ha J,Park KJ,Kim YJ

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND AND AIM:For reduction in cost, time and risk of complications, the number of endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) passes should be minimized. Previous studies have shown that tumor differentiation and site of aspiration will affect the number of passes in patients with pancreatic c...

journal_title：Journal of gastroenterology and hepatology

authors： Cheng TY,Wang HP,Jan IS,Chen JH,Lin JT

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Lung injury is an important target for the systemic inflammatory response associated with intestinal ischemia/reperfusion (I/R). In the present study, the role of interleukin (IL)-18 in the development of acute pulmonary injury induced by intestinal I/R and its possible mechanism in relation to the ...

journal_title：Journal of gastroenterology and hepatology

authors： Yang YJ,Chen SH,Ge XR

更新日期：2007-02-01 00:00:00

abstract：AIM:We compared the epidemiology and clinical features of hepatocellular carcinoma (HCC) cases diagnosed between 1975 and 2002. METHODS:Retrospective and prospective analysis was performed of HCC cases diagnosed at The Alfred during the time periods 1975-1983 and 1995-2002. Demographic, epidemiological, clinical and l...

journal_title：Journal of gastroenterology and hepatology

authors： Roberts SK,Kemp W

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Thrombocytopenia is a common manifestation of liver cirrhosis (LC), but its underlying mechanism is not fully understood. The purpose of the present paper was to evaluate the platelet kinetics in LC patients by examining several non-invasive convenient markers. METHODS:Fifty-seven LC patients, 32 patients w...

journal_title：Journal of gastroenterology and hepatology

authors： Kajihara M,Okazaki Y,Kato S,Ishii H,Kawakami Y,Ikeda Y,Kuwana M

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Esophagogastric devascularization is an operation that can be performed for endoscopically uncontrolled variceal bleeding in hospitals having only basic surgical instruments and is therefore an appropriate procedure for small hospitals in developing countries. The aim of this study was to analyze one hospita...

journal_title：Journal of gastroenterology and hepatology

authors： Goyal N,Singhal D,Gupta S,Soin AS,Nundy S

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Oxidative stress plays an important role in the pathogenesis of chronic liver diseases. The plasma level of 8-isoprostane, a product of lipid peroxidation, is a marker of oxidative stress in vivo. The aim of the present study was to clarify whether the degree of lipid peroxidation, as measured by the plasma ...

journal_title：Journal of gastroenterology and hepatology

authors： Konishi M,Iwasa M,Araki J,Kobayashi Y,Katsuki A,Sumida Y,Nakagawa N,Kojima Y,Watanabe S,Adachi Y,Kaito M

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Overexpression of signaling proteins including epidermal growth factor receptor (EGFR), Akt, mitogen activated protein kinase (MAPK) and cyclooxygenase-2 (COX-2) occurs in cholangiocarcinoma cell lines. However, the prognostic value of these markers is unknown. No prior study correlated the expression of the...

journal_title：Journal of gastroenterology and hepatology

authors： Javle MM,Yu J,Khoury T,Chadha KS,Iyer RV,Foster J,Kuvshinoff BW,Gibbs JF,Geradts J,Black JD,Brattain MG

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder in the West. But information on the prevalence of IBS in Asia is still lacking, especially in Korea. Therefore, the aims of the present study were to estimate the prevalence of IBS in the general population of Korea and also to i...

journal_title：Journal of gastroenterology and hepatology

authors： Han SH,Lee OY,Bae SC,Lee SH,Chang YK,Yang SY,Yoon BC,Choi HS,Hahm JS,Lee MH,Lee DH,Kim TH

更新日期：2006-11-01 00:00:00

abstract：:The identification of activated hepatic stellate cells and related cell types as key fibrogenic effectors during liver injury has led to intense evaluation of transcriptional events underlying their behavior. While initial studies focused on characterizing interactions between transcription factors and regulatory regi...

journal_title：Journal of gastroenterology and hepatology

authors： Friedman SL

更新日期：2006-10-01 00:00:00

abstract：:Alcoholic liver disease (ALD) remains a leading cause of death in the USA. Defining mechanisms for liver cell death in ALD in order to develop potential new agents for therapeutic intervention is a major focus of the authors' work. Abnormal cytokine metabolism is a major feature of ALD, and a thorough understanding of...

journal_title：Journal of gastroenterology and hepatology

authors： Barve S,Joshi-Barve S,Song Z,Hill D,Hote P,Deaciuc I,McClain C

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND AND AIM:The attenuated antisecretory activity of H2 receptor antagonists (H2RA) during continuous administration is known as the tolerance phenomenon. The authors recently clarified that presence or absence of Helicobacter pylori infection influences the occurrence of the tolerance phenomenon. The aim of thi...

journal_title：Journal of gastroenterology and hepatology

authors： Furuta K,Adachi K,Komazawa Y,Mihara T,Miki M,Azumi T,Fujisawa T,Katsube T,Kinoshita Y

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND AND AIM:Extracorporeal shockwave lithotripsy (ESWL) has an established role in the management of pancreatic ductal stones. Its efficacy in management of multiple stones in tropical pancreatitis is unknown. The aim of this study was to prospectively evaluate: (i) the efficacy of main pancreatic duct stone cle...

journal_title：Journal of gastroenterology and hepatology

authors： Ong WC,Tandan M,Reddy V,Rao GV,Reddy N

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Antibody against hepatitis B surface antigen (HBsAg) is used for passive immunotherapy in certain cases of hepatitis B infection. The authors have earlier reported a high-affinity mouse monoclonal (5S) against HBsAg. However, this mouse antibody cannot be used for therapeutic purposes because it may elicit a...

journal_title：Journal of gastroenterology and hepatology

authors： Bose B,Khanna N,Acharya SK,Sinha S

更新日期：2006-09-01 00:00:00

abstract：AIM:Rabeprazole has been known to inhibit H(+)/K(+)-ATPase more rapidly than omeprazole, the prototype proton pump inhibitor (PPI). The aim of this study was to demonstrate equivalence between low-dose rabeprazole 10 mg and omeprazole 20 mg for the healing rapidity of active peptic ulcer and for improvement of symptoms...

journal_title：Journal of gastroenterology and hepatology

authors： Ji S,Kim HS,Kim JW,Jee MK,Park KW,Uh Y,Lee DK,Song JS,Baik SK,Kwon SO

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:The purpose of the present paper was to determine informed consent practices for inpatient, open-access colonoscopy and endoscopic retrograde cholangiopancreatography (ERCP) at a tertiary referral center. METHODS:A two-part prospective study incorporating (i) an audit of consent practices for colonoscopy an...

journal_title：Journal of gastroenterology and hepatology

authors： Seow CH,Leber JM,Ee HC,Yusoff IF

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND AND AIM:The present study was designed to investigate the expression of and humoral response against NY-ESO-1 in patients with hepatocellular carcinoma and to analyze the relationship between expression of NY-ESO-1 mRNA and clinicopathological features. METHODS:NY-ESO-1 mRNA and protein expression in surgic...

journal_title：Journal of gastroenterology and hepatology

authors： Nakamura S,Nouso K,Noguchi Y,Higashi T,Ono T,Jungbluth A,Chen YT,Old LJ,Nakayama E,Shiratori Y

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:The reasons for the viral persistence of hepatitis B virus infection (HBV) are unknown, but are probably related to host immune factors. Cytokines play a significant role in immune defense. The present study was undertaken to investigate the association between HBV infection and polymorphisms of tumor necros...

journal_title：Journal of gastroenterology and hepatology

authors： Cheong JY,Cho SW,Hwang IL,Yoon SK,Lee JH,Park CS,Lee JE,Hahm KB,Kim JH

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND AND AIMS:The relationship between gastroesophageal reflux disease and sliding hernia is controversial, especially following distal partial gastrectomy in patients with gastric cancer. The aim of this study was to examine the relationship between gastroesophageal reflux disease and sliding hernia of the esoph...

journal_title：Journal of gastroenterology and hepatology

authors： Fujiwara Y,Nakao K,Inoue T,Koishi K,Nishio Y,Yagyu R,Nakagawa K,Yamamura T

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND AND AIM:Hepatic arterial infusion (HAI) chemotherapy has a number of limitations, including a low rate of complete response and frequent extrahepatic recurrence, in colorectal cancer patients with non-resectable hepatic metastases. METHODS:Twenty-nine colorectal cancer patients with non-resectable hepatic m...

journal_title：Journal of gastroenterology and hepatology

authors： Kim JC,Kim HC,Lee KH,Yu CS,Kim TW,Chang HM,Ryu MH,Kim JH,Ha HK,Lee MG

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:The purpose of the present paper was to investigate dendritic cell (DC) and T-cell functions in patients with chronic hepatitis B (CHB) and determine whether therapeutic DC vaccines could restore T-cell function in those patients in vitro. METHODS:Twelve patients with CHB and 10 normal control subjects with...

journal_title：Journal of gastroenterology and hepatology

authors： Duan XZ,He HX,Zhuang H

更新日期：2006-06-01 00:00:00